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KMID : 0869619970140040301
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Journal of Korean Society of Hospital Pharmacists
1997 Volume.14 No. 4 p.301 ~ p.304
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The comparison of blood glucose levels following the administration of gliclazide 30 minutes before and after meal
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Abstract
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This study was designed to compare the blood glucose levels when gliclazide was administered to the DM patients 30 minutes before and after meal. We selected 14 patients according to specific guidelines. Patients were divided into two groups. One group was administered gliclazide 30 minutes before meal and the other group was administered gliclazide 30 minutes after meal. After one month, both groups had standard meals (75 g OGTT), and then, blood glucose was measured every 30 minutes for two hours. After the first month, the groups switched administering times. After one month, blood glucose was measured as before. AUC was obtained from the curve of blood glucose concentration for the two groups, but differences between the groups were not significant (p>0.05). This result have shown that the administration time of gliclazide in relation to the meal should lay emphasis on compliance with patients.
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